vascular SASP in aged skeletal muscleExample conversation
Iteration 12 complete. JUNB is the dominant vascular SASP driver — rho=0.923, p=3.64×10⁻¹⁰, N=23 donors. Cross-replicated in Nature Aging (rho=0.720).
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What about FAPs? I thought they were the primary senescence source.
Opposite pattern — all seven AP-1 subunits show negative coupling in FAPs. C/EBPβ leads instead (rho=0.802, p<10⁻⁵). Therapeutic implication: JNK pathway modulation for vascular SASP; FAPs need a different strategy entirely.