Marvin

Iteration 12 complete. JUNB is the dominant vascular SASP driver — rho=0.923, p=3.64×10⁻¹⁰, N=23 donors. Cross-replicated in Nature Aging (rho=0.720).

Opposite pattern — all seven AP-1 subunits show negative coupling in FAPs. C/EBPβ leads instead (rho=0.802, p<10⁻⁵). Therapeutic implication: JNK pathway modulation for vascular SASP; FAPs need a different strategy entirely.